Prostate diseases are often accompanied by inflammation and spasms of the urinary tract. In this case, urinary disorders occur - incontinence or urinary retention. Alpha adrenergic blockers for prostate adenoma and prostatitis help other medications to be better absorbed, and also improve urination and reduce pain.
What types exist and how do they work?
The drugs are divided into groups depending on which receptors they affect:
- Alpha adrenergic receptors (1 and 1,2). They are located in the organs of the genitourinary system. When exposed to them, muscle spasm is relieved and urination is facilitated.
- Alpha-2 adrenergic receptors are responsible for muscle contraction. When exposed to them, vasodilation occurs; they are prescribed for erectile dysfunction.
- Beta blockers (1 and 1.2). They are responsible for the strength and frequency of heart contractions, the tone of arterioles and bronchi.
Medicines that act on only one receptor are called selective. Acting on several receptors – non-selective.
Medicines of the first group have the same effect on the body. They differ in that when taking drugs that act on 2 groups of receptors at once, a greater number of side effects appear and their occurrence occurs more often than with drugs acting on 1 type.
When taken, the blood vessels and muscles of the genitourinary system relax. As a result, the penetration of other drugs into inflamed tissues improves and the symptoms of diseases are relieved:
- swelling is relieved;
- urine flow improves;
- false urge to urinate disappears;
- pain in the perineum decreases;
- erection improves;
- pain during ejaculation disappears.
When prescribing alpha adrenergic blockers for the treatment of prostatitis and prostate adenoma, the doctor most often chooses selective drugs. Non-selective drugs can have an effect on neighboring organs, which affects the general condition of the body.
Beta blockers are most often prescribed for diseases of the cardiovascular system. For prostatitis and prostate adenoma, they can be prescribed to reduce libido. Combined use with medications of the first and second groups is not recommended.
The most effective drugs
There are a large number of drugs related to adrenergic blockers on sale. They are classified as prescription drugs, so the choice of drug is determined by the attending physician. It is based on studying the symptoms of the disease and the presence of contraindications.
Alpha-1 blockers
For prostate adenoma and prostatitis, drugs from the first group of alpha adrenergic blockers are prescribed. They block receptors located in the tissues of the prostate and bladder, causing muscle relaxation, spasm relief and improved urination. They relieve symptoms of prostate hyperplasia, improve the tone of blood vessels and veins, have a dilating effect on the circulatory system, increase the level of good cholesterol and reduce the level of harmful cholesterol.
Popular commercially available alpha-1 adrenergic blockers are classified according to the active substance:
- Alfuzosin (Dalfaz, Dalfaz retard, Alfuprost MP, Alfuzosin).
- Doxazosin (Kamiren HL, Artezin, Cardura).
- Terazosin (Cornam, Setigs, Terazosin).
- Tamsulosin (Omnic, Focusin, Proflosin).
Alpha-2 blockers
Drugs of the second group of alpha-blockers for the treatment of prostatic hyperplasia are prescribed if the patient has urinary incontinence, as well as for sexual dysfunction to increase libido. This group of drugs includes drugs containing yohimbine:
- Yohimbine.
- Yohimbine Spiegel.
- Yohimbine hydrochloride.
When using alpha-2 adrenergic blockers for prostate diseases, it is necessary to control blood pressure.
Beta blockers
Beta-blockers - drugs of the third group are rarely prescribed for prostate adenoma. Their appointment is justified if it is necessary to reduce sexual activity.
This group of drugs includes drugs containing:
- Metoprolol (Egilok, Metocard, Betalok).
- Sotalol (Sotalex, Sotalol, Sotahexal).
- Nebivolol (Nebilet, Binelol).
